212 in the world, Tsonga received a wild card entry into the 2007 Australian Open, where in only his second senior Grand Slam tournament match, he met sixth seed Andy Roddick for the second time in his career.

[24] In the round-robin portion of the Masters Cup, Tsonga lost to Nikolay Davydenko and Juan Martín del Potro, and beat Novak Djokovic, but he did not advance to the semifinals.

The duo had beaten Travis Parrott and Filip Polášek, Simon Aspelin and Pavel Vízner, and Mario Ančić and Paul-Henri Mathieu en route to the finals.

At the BNP Paribas Open in Indian Wells, California, Tsonga made an early exit from the tournament, as he was defeated by the Russian Igor Andreev in the third round.

After skipping two tournaments, Tsonga made his return at the Internazionali BNL d'Italia in Rome, but he lost his first singles match in the clay-court season at the hands of Richard Gasquet.

At 2010 Dubai Tennis Championships, he won against Michaël Llodra, who retired due to injury, but then struggled with form and lost to Ivan Ljubičić in the second round.

In the singles, Tsonga helped France take an unassailable 3–0 lead, by winning the second-rubber match against Benjamin Becker, but was forced to retire against Simon Greul due to a recurring injury.

Tsonga made his return in October for his title defense at the 2010 Rakuten Japan Open Tennis Championships as the third seed, but rustiness was apparent, and he lost early to Jarkko Nieminen.

Entering the 2010 Shanghai Rolex Masters 1000 as the 12th seed, Tsonga had wins over Feliciano López, Sam Querrey, and Florian Mayer, before losing in the quarterfinals in straight sets to eventual champion Andy Murray.

At the Qatar ExxonMobil Open, Tsonga defeated Rubén Ramírez Hidalgo, Sergey Bubka, and Guillermo García López, before losing to Roger Federer in the semifinal.

He defeated Bulgarian Grigor Dimitrov, Michaël Llodra, and Ivan Ljubičić to reach his first final since winning the Japan Open in 2009, but lost there to Robin Söderling.

Tsonga then found some form at the 2011 Mutua Madrid Open, beating first-time top-10 debutant Nicolás Almagro, before losing to Robin Söderling in the third round.

This proved to be a good tournament for Tsonga, with wins over Lleyton Hewitt, Guillermo García López, Lukáš Lacko, Mardy Fish, and Philipp Kohlschreiber.

The pair won their opening match against Argentinians David Nalbandian and Eduardo Schwank, and followed it with a win over India's Leander Paes and Vishnu Vardhan.

In the finals, they faced the top seeded Americans Mike and Bob Bryan, but lost in straight sets, thus winning the Olympic silver medal.

France finished bottom of their group, but despite injuring himself at Hopman Cup, Jo was declared fit for the 2013 Australian Open, where he reached the quarterfinals but lost a thrilling five setter against Roger Federer.

Impressively, Tsonga defeated three of the Big Four in a single tournament, capturing victories over Novak Djokovic in the third round, Andy Murray in the quarterfinals, and Federer in the final.

After a quiet, injury-hit start to the season in which Tsonga did not play at the Australian Open, he began his 2015 campaign at Miami, where he beat Tim Smyczek but lost to Gaël Monfils in the second round.

Tsonga won his twelfth singles title and third at the Moselle Open in Metz, France with a victory over compatriot Gilles Simon in a hard-fought three-set final match.

Tsonga, the sixth seed, retired with an adductor muscle injury from his French Open third-round match against Latvia's Ernests Gulbis when he was leading 5–2 in the first set.

After struggling to string wins over the summer and the early autumn, Tsonga returned to the winner's circle in October, defeating Diego Schwartzman in straight sets to capture his fourth ATP World Tour singles title of the year at the European Open in Antwerp.

Tsonga was called up to play for France in the 2018 Davis Cup World Group first-round tie against the Netherlands, but he withdrew one day before the start of the first singles match because of a knee injury.

[40] Tsonga pulled out of five ATP World Tour tournaments that were to be held in February, March and April (Rotterdam, Marseille, Indian Wells, Miami and Monte-Carlo) due to injuries.

A month later, having skipped Indian Wells, Tsonga entered the qualifying round of the Miami Open, where he beat Lukas Rosol before losing in straight sets to Pablo Cuevas.

[55] He then played the ATP 500 Halle Open, where he beat Benoît Paire in two tight sets, before facing his rival and at that time 9-time champion of the tournament Roger Federer in the 2nd round.

[56] Tsonga made the third round of Wimbledon, after straight-set wins over Bernard Tomic and Ričardas Berankis, and lost in straight sets to world number 2 Rafael Nadal.

[67] Their first meeting was in the final of the 2008 Australian; Djokovic and Tsonga had defeated the top two players, Roger Federer[68] and Rafael Nadal[69] in their respective semifinals in straight sets.

It was their first meeting on grass, and Djokovic prevailed in four sets to advance to his first Wimbledon final,[72] and in the process ending the seven-and-a-half-year reign of Roger Federer and Rafael Nadal at the top of the rankings.

Tsonga's serve is one of his fastest, strongest and most dominant shots, mixing both slice and speed, enabling him to create and win easier points, such as an ace or a one-two-punch.

In general, Tsonga has struggled on clay, although his clay-court skills improved as his career progressed, as evidenced by his 2012 season, where he reached the quarterfinals at the French Open, Monte-Carlo, and Rome.