[2] Cosío played a character named Hector, a multi-episode role in the HBO comedy Eastbound & Down.

[3] He played General Medrano, one of the main villains in the James Bond film Quantum of Solace,[2] and acted alongside Benicio del Toro in Oliver Stone's gritty thriller, Savages.

Cosío appeared in Robert Duvall's A Night in Old Mexico, and in Disney's 2013 film The Lone Ranger.

[2] In 2005 for Ariel Award for Best Supporting Actor for his portrayal of the lovable and ruthless "Mascarita" in the Mexican box office hit Matando Cabos,[5] and again in 2011 for his work in the film El Infierno.

[5] In 2016, he finally won Ariel Award for Best Supporting Actor for his work as Gabriel in The Thin Yellow Line.