He edited writings by Mexican writers who preceded him, wrote a biography of Juan de Zumárraga, and translated William H. Prescott's Conquest of Mexico.
He also highlighted the Archbishop's role in fostering early educational institutions such as the Colegio Santa Cruz and credits him with bringing the first printing press to the Western hemisphere.
He also used the book to criticize the hypocrisy he viewed in Liberal legislators, who, while attacking the Archbishop for cruelty to the Indians, betrayed the indigenous heritage of the nation by lifting limitations on the export of ancient works of art and artifacts.
In fact, García Icazbalceta had written a chapter on the subject, which he elected not to include in the final draft at the behest of Francisco Paula de Verea, bishop of Puebla.
In response to a demand made by Pelagio Antonio de Labastida, Archbishop of Mexico, he wrote a detailed account of "what history tells us about the apparition of Our Lady of Guadalupe to Juan Diego".