Andruzzi was born in Brooklyn and played high school football at Tottenville High School in the Huguenot neighborhood of Staten Island, where his classmates included former Major League Baseball All-Star starting pitcher Jason Marquis and former National Football League player Adewale Ogunleye with the Miami Dolphins and Chicago Bears Andruzzi played college football at Southern Connecticut State University in New Haven, Connecticut, where he majored in special education.

He was allocated by the Packers in February 1998 to play football in Scotland in the NFL Europe league.

After becoming a free agent in 2005, he rejoined former Patriots defensive coordinator and new head coach Romeo Crennel in Cleveland, signing a 4-year deal worth $9 million.

[3] The family relocated back to New England where Andruzzi had an aggressive form of chemotherapy treatment over three months at Dana–Farber Cancer Institute and Brigham and Women's Hospital.

Andruzzi received the 2015 Man of the Year award from the Walter Camp Football Foundation.

[4] Andruzzi has three brothers, each of whom are members of the New York City Fire Department who responded to the September 11 attacks on the World Trade Center.