He played college football at the Carlisle Indian Industrial School from 1912 to 1913 and Georgia Tech from 1917 to 1918 and with a number of professional clubs from 1919 to 1927.

[2] Guyon attended and played college football at the Carlisle Indian Industrial School from 1912 to 1913 under head coach Pop Warner.

[4] In the game against Army featuring the likes of future US President Dwight D. Eisenhower, Leland Devore was ejected for manhandling Guyon.

[3] From 1914 to 1915, Guyon attended the Keewatin Academy in Prairie du Chien, Wisconsin,[6] to regain college eligibility.

[7] Guyon then attended and played football at Georgia Tech from 1917 to 1918 under head coach John Heisman.

For his time spent playing at Georgia Tech, Guyon was a unanimous selection for an Associated Press Southeast Area All-Time football team 1869-1919 era.

[8] Fullback Judy Harlan said about Guyon, "Once in a while the Indian would come out in Joe, such as the nights Heisman gave us a white football and had us working out under the lights.

"[9] The 1917 team went 9–0, scored 491 points, was crowned national champion, and was for many years considered "the greatest the South ever produced.

"Strupper, Guyon, Hill, and Harlan form a backfield with no superiors and few equals in football history" wrote the Times-Picayune.

[23] Guyon had previously hit over .340 three consecutive years for the Louisville Colonels in the American Association, which at AA, was at the highest classification of the era.