He played in Major League Baseball as a right fielder from 1968 through 1973 for the Oakland Athletics, Kansas City Royals and the Chicago White Sox.

Keough batted and threw left-handed, stood 6 feet (1.8 m) tall and weighed 185 pounds (84 kg).

He had a promising debut with the Oakland Athletics at Yankee Stadium on August 7, 1968, when he hit a home run off Lindy McDaniel in his first major league at bat.

After being the fourth player selected by the Royals in the 1968 Major League Baseball expansion draft, he was on the Opening Day roster when Kansas City played its first game in April 1969.

Keough delivered a pinch-hit single in the bottom of the 12th inning of the inaugural contest, giving KC a 4–3 victory over the Minnesota Twins.