[2] Weisberg is best known as the creator and showrunner of the FX TV series The Americans and The Patient (co-created with Joel Fields).

A 1987 graduate of Yale University, Weisberg became a CIA officer three years after graduation,[2] and after a short career with the Agency, Weisberg taught at The Summit School, a private special education high school in Queens, New York City until 2010 when he went on to pursue a career in television.

[3] Weisberg wrote episodes for TNT's alien invasion series Falling Skies and the DirecTV legal drama Damages.

[7] Weisberg is also the author of the non-fiction book Russia Upside Down: An Exit Strategy for the Second Cold War, which was published in 2021.

[2] In 2024, Weisberg and The Americans co-showrunner Joel Fields signed an open letter by more than 1,000 Jewish creatives and professionals denouncing Jonathan Glazer's acceptance speech for The Zone of Interest at the 96th Academy Awards, in which Glazer had criticized Israel's actions during the Israel-Hamas war, as well as the Israeli occupation of Palestinian Territories.