[3] Returning to help lead the Runnin' Rebels to a 30–7 season his senior year (2006–07), he was named Mountain West Conference defensive player of the year[3][5][6][7][8] after finishing second in the NCAA's Division I in blocks-per-40-minutes (6.77), and first in the conference in blocked shots, blocks per game, and defensive win shares.

The highlight in Anthony's senior year was his only double-double of the season, a season-high 13-block, 11-rebound effort versus Texas Christian on February 7, 2007.

The following year Anthony made his NBA playoff debut during Miami's first-round series with the Atlanta Hawks.

[12] With Miami's high-profile free agent signings of LeBron James and Chris Bosh in July 2010 much hype surrounded the team with its new self-proclaimed "Big Three".

Anthony won his second championship on June 20, 2013, when the Heat defeated the San Antonio Spurs in an intense seven game series.

On January 15, 2014, a three-team trade was completed involving the Miami Heat, the Boston Celtics, and the Golden State Warriors.

[29] On February 27, 2018, Anthony signed with San Lorenzo of Argentina's Liga Nacional de Básquetbol (LNB), as a temporary replacement for injured power forward-center Matías Sandes.

[32] During the summer of 2006, Anthony was selected to join the Canadian senior national team and participated with the squad, touring three European countries: Italy, Germany, and Slovenia.

He made a tremendous impact on the court for the Canadians, by setting both scoring and shot-blocking records for an individual game.

[34] On May 21, 2020, the Hamilton Honey Badgers of the Canadian Elite Basketball League (CEBL) announced that they had appointed Anthony as player consultant.

[36] His mother is Erene Anthony from the island of Antigua, who he listed on his biography as the person that made a difference in his life because she has been an inspiration to him.

[38] The nickname started gaining traction on Twitter after the Heat beat the Knicks in New York on December 17, 2010,[39] and fans credited Anthony for "locking up" Amar'e Stoudemire.