He has worked with such noted artists as pianists Vladimir Feltsman and Lorin Hollander, violinist Jaime Laredo, Metropolitan Opera singers Florence Quivar and Roberta Alexander.
For thirteen years, Thome led the National Symphonic Orchestra of Mexico in concerts of classical and contemporary works.
He has also conducted the Israel Chamber Orchestra, Group L'Itineraire in Paris, Brooklyn Philharmonic, the Orquestra Municipal of Caracas and the Milwaukee Symphony, and has been a regular guest conductor of the Monday Evening Concert Series in Los Angeles.
Thome has held a number of prestigious positions in academe and for some years was Head of Music at Carnegie Mellon University.
Thome major compositions include Savitri Traveller of the Worlds, the score for Picasso's play Catch Desire by the Tail; Book of Beginnings V for Benny Reitveldt (bassist for Miles Davis and Carlos Santana), and Time Spans, the first work to use actual radio signals from space.