[2] He worked on the television series Perfect Strangers, Full House, and Family Matters, and directed the films My Big Fat Greek Wedding, Second Sight, and Fat Albert.

[citation needed] Zwick has directed 21 television pilots, all of which have continued on to successful runs as weekly series.

Despite a popular misconception, he is not related to fellow filmmaker Edward Zwick.

Zwick was active in the Off-Off-Broadway movement at La MaMa Experimental Theatre Club, which was founded by Ellen Stewart in 1961.

He worked with the La MaMa Plexus company at the East Village theater and on tour both domestically[7] and internationally.