[4] After high school, Fatone played "Wolfie" in Beetlejuice's Rock and Roll Graveyard Revue at Universal Studios Florida in Orlando.

[5] There, in the summer of 1995, he befriended fellow park performer Chris Kirkpatrick who recruited him as the fourth member of a new vocal group that included Justin Timberlake and JC Chasez.

Fatone sang baritone with the band from their formation to 2002, when they went on an indefinite hiatus, during which time they sold more than 70 million records worldwide.

While a member of NSYNC, Fatone co-starred with bandmate Bass in the 2001 romantic comedy film On the Line and guest-starred with the band on The Simpsons episode, "New Kids on the Blecch".

[7] In April 2019 the band reunited without Timberlake for a one-off performance with Ariana Grande at the Coachella Valley Music and Arts Festival.

[13][14] He went on to act in the critically acclaimed movie The Cooler and had minor roles in the experimental film Red Riding Hood and Homie Spumoni, the latter alongside Jamie-Lynn Sigler.

He returned to Broadway in 2004 in a revival of Little Shop of Horrors[15] and later appeared in productions of The Producers and 42nd Street in Pittsburgh[16] and Rock of Ages at Bally's Las Vegas.

Fatone played himself in the kung fu skit "Enter the Fat One" in the first season of Robot Chicken, later making more appearances on the show including the first Star Wars episode.

He also played himself in the Syfy film Jersey Shore Shark Attack, the TV series Return of the Mac and the Comedy Central feature Cursed Friends.

Fatone has guest-starred in the Disney Channel series Hannah Montana, Imagination Movers and Kim Possible in addition to various other TV shows and horror films, including Inkubus (2011) and Dead 7 (2016).

He made repeat appearances on the show as host or featured guest in a number of specials, including a 2017 episode based at his Orlando hot dog restaurant, Fat One's.

Fatone portrayed "Rabbit" on the first season of the singing competition show The Masked Singer, tying with Rumer Willis as "Lion" for fourth place overall.

On February 1, 2007, the ABC television network announced that Fatone would participate in season 4 of the American version of Dancing with the Stars, which debuted March 19, 2007.

In February 2013, Fatone appeared on Holland America Line's "Dancing with the Stars at Sea", aboard the MS Eurodam.

On September 9, 2004, Fatone married Baldwin at Oheka Castle on Long Island, New York, in a ceremony that was attended by all his NSYNC bandmates.