Primarily known as a keyboard player, Huffman has performed as a member of the bands Witness, Drivin N Cryin and the Georgia Satellites.
[1] Also known for his work in music production, he has been credited on albums such as Bowling for Soup's A Hangover You Don't Deserve, Skinny Molly's Here For A Good Time, Miranda Lambert's Kerosene, Soul Asylum's Let Your Dim Light Shine,m, Black Gold: The Best of Soul Asylum and Silver Lining, Meat Puppets' No Joke, Matchbox Twenty's Live From Down Under DVD, Butch Walker's Letters, CeeLo Green's Cee-Lo Green and His Perfect Imperfections, Collective Soul's Youth, Izzy Stradlin's Miami, Blackberry Smoke's New Honky Tonk Bootlegs.
He has toured with Isaac Hayes (1989), Michelle Malone and Drag the River (1990–1991), The Georgia Satellites (1992–2004), Drivin N Cryin (1994–2006), Izzy Stradlin (1993), Matchbox Twenty (1998) and Soul Asylum (1993–1997).
Rick Richards, Peter Stroud, Cindy Wilson, Eddie (Cowboy) Long, Charlie Starr, and others have made guest appearances on albums he has produced.
On November 3, 2023, Izzy Miller released the three-track live extended play, A Triple in Bristol with Huffman and Sonny Tackett.