[1] The Houston Astros selected Loperfido in the seventh round of the 2021 Major League Baseball draft.
[5] In his debut, he hit a two RBI single against Cleveland Guardians pitcher Carlos Carrasco.
[6] On May 27, Loperfido was demoted to Sugar Land to make room on the roster for José Abreu.
[7] In 38 total games for Houston, he slashed .236/.299/.359 with two home runs, 16 RBI, and two stolen bases.
On July 29, 2024, Loperfido, Jake Bloss, and Will Wagner were traded to the Toronto Blue Jays in exchange for pitcher Yusei Kikuchi.