Nicknamed Dinamita (Spanish for dynamite), he is also known among fans for his humbleness and love to Latin music such as reggaeton and salsa.

[2][3][4] Joffre David Guerrón Méndez, was born in a small Ecuadorian village called Ambuquí at the Imbabura Province, place where other important figures of Ecuadorian football have emerged, players such as Édison Méndez, Agustín Delgado, Ulises de la Cruz and Giovanny Espinoza.

Guerrón made his debut in the top Ecuadorian division with SD Aucas at the very young age of 16.

He impressed and dazzled many with his speed and talent as well as his pace in the 2008 Copa Libertadores with LDU Quito, scoring against Libertad of Paraguay with an individual play, and also against Estudiantes de La Plata, where Guerron took the ball individually past several defenders and shot the football very powerfully past the small space left on the goal-keeper's left side.

Guerron in the semi-final versus Club America received a long pass from Jayro Campos on the right side of the field, dribbled past his defender to send the ball past Guillermo Ochoa and leave it for Luis Bolanos to just head the ball in, resulting in an important 1–1 away result.

After drawing to America 0–0 at home, Liga reached the final where Guerrón played an important role in the victory over Fluminense, scoring a goal in the first leg, then putting in an energetic performance before scoring LDU's third goal in the 3–1 penalty shootout victory.

He was member of the team that won Copa Libertadores in 2008, Liga Deportiva Universitaria de Quito.

As a result, Swiss club teammate Fabio Celestini condemned the racist supporters in a later press conference calling them idiots and also praising Guerrón's attitude throughout the match,[5] although it was suggested that Joffre did not know the insults were directed at him.

In his 2009 season, he played 15 league games, scoring two goals in two victories against Santo Andre and Sport Recife.

On 4 February, in a 2010 Copa Libertadores match, he scored a goal in 7–0 win against Bolivian club Real Potosi.

On 23 April, in an AFC Champions League group match against Korean giants Pohang Steelers, Guerron scored the opening goal in a 2–0 home win.

He scored his first goal via penalty-kick in an Apertura 2014 Copa MX game against Estudiantes de Altamira in the victory of 4–0 at the Estadio Universitario on 29 July.

On 16 August, Guerrón scored his first goal in a League game, on the 1–1 draw against Puebla FC, at the Estadio Cuauhtémoc.

[8] He was called up for the first two 2010 World Cup qualifiers in October 2007 against Venezuela and Brasil and more recently against Argentina and Colombia.

Coach Reinaldo Rueda has called Guerron back for international duty for World Cup qualifier matches.