[1] It is located between the Central Business District and Braamfontein, in the block bordered by Rissik, Wolmarans, Wanderers, and Noord Streets.

Park Station lies on the main Witwatersrand railway line that runs East-West from Krugersdorp to Germiston.

Park Station is the centre of the Witwatersrand Metrorail network, with daily commuter rail services running west to Carletonville, Randfontein and Soweto; east to Springs, Nigel and Daveyton; north to Pretoria and south to Vereeniging.

[2] Park Station is also the terminus of Shosholoza Meyl long-distance services to Cape Town, Durban, Port Elizabeth, East London, Bloemfontein via Kimberley, Komatipoort via Nelspruit and Musina via Polokwane.

[4]: 6  The line was run by the De Nederlandsche Zuid-Afrikaansche Spoorweg Maatschappy (NZASM) and was known as the Rand Steam Tram which transported coal from the collieries at Boksburg to the yards at Braamfontein.

[5]: 151  The NZASM planned to build a railway from Pretoria to the border of Portuguese East Africa (now Mozambique), the aim being to have an independent link to the Indian Ocean, bypassing British territory in the Cape and Natal.

[4]: 7  This was soon followed by the ZAR's project to connect Pretoria to Delagoa Bay, with the first train arriving in Johannesburg from Lourenco Marques (Maputo) on 2 November 1894.

[4]: 9 On the night of 5 July 1913, Park Station was damaged by fire during looting and rioting, after rioters cut open the fire-brigades hoses.

There was opposition to the idea by the people of Johannesburg when a 100 ft strip of the Wanderers ground was proposed with the South African Railways offering £31,000 and the club wanting the amount doubled.

[4]: 14 The new station would be constructed in four stages between 1948 and 1965, designed by the architects Kennedy, Furner, Irvine-Smith & Joubert with civil engineering consultant firm A.S.

[4]: 15  Later stages involved concrete covers over the platforms and the concourses built on top with the slabs over the suburban station completed in 1956 and main lines by 1961.

[4]: 14 On 24 July 1964, Frederick John Harris of the African Resistance Movement planted a bomb on a whites-only platform of the Station.

[9] It was revealed in 2018 that Park Station has become a hub for abduction of women and children who commute or work in the area, who then become victims of human trafficking.

[10] Park Station is also the site of the southern terminus of the Gautrain, a high-speed rail link to Pretoria and the OR Tambo airport.