Griffin played college baseball under head coach Mike Martin for the Florida State University Seminoles from 1999 to 2001.

[1] On July 5, 2002, Griffin, and future Blue Jays teammates Ted Lilly and Jason Arnold were traded to the Oakland Athletics as part of a three-team deal also involving the Detroit Tigers that sent Jeff Weaver to the Yankees.

[4][5] Griffin made his major league debut and collected his first major-league hit, a double, on September 6, 2005, in a game against the Baltimore Orioles.

On the final day of the regular season, he hit his first Major League home run against Kansas City Royals pitcher Jimmy Gobble.

[8] In 2010, Griffin played for the Newark Bears of the Atlantic League of Professional Baseball, but announced his retirement on June 18, 2010.