Fox practiced in Boston for fifty years and is best remembered for his works in the Stick Style.
In 1858 he joined the office of Boston architect Benjamin F. Dwight, with whom he remained until the outbreak of the Civil War.
The couple lived in a house of Fox's own design at 25 Trull Street in Dorchester.
[4] The Boston historian Anthony Mitchell Sammarco has referred to Fox as the "Father of Stick Style architecture.
[10] Several of Fox's works, including the campus of the Tewksbury Hospital, have been listed on the United States National Register of Historic Places.