As a correspondent for ABC, Scali became an intermediary during the Cuban Missile Crisis and later a part of the Nixon Administration.

Scali gained fame after it became known in 1964 that in October 1962, a year after he joined ABC News, he had carried a critical message from KGB Colonel Aleksandr Fomin (the cover name for Alexander Feklisov) to U.S. officials.

He left ABC in 1971 to serve as a foreign affairs adviser to President Nixon, becoming U.S.

Scali was contacted by Soviet embassy official (and KGB Station Chief) Fomin about a proposed settlement to the crisis, and subsequently he acted as a contact between Fomin and President Kennedy and the Executive Committee.

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