[1] Berkeley was returned to parliament as one of two representatives for Stockbridge in 1735, a seat he held until 1741, when he succeeded his father in the barony and took his seat in the House of Lords.

[1][2] In 1743 he was appointed Captain of the Yeomen of the Guard, which he remained until 1746.

He was sworn of the Privy Council in 1752[3] and served as Treasurer of the Household between 1755 and 1756 and Captain of the Honourable Corps of Gentlemen Pensioners between 1756 and 1762.

[1][4] Lord Berkeley of Stratton was married but had no children.

He died at a family home, Bruton Abbey, Somerset, in April 1773, aged 75, when the barony became extinct.