John Bryson (June 20, 1819 – October 11, 1907) was an American businessman who served as the 19th Mayor of Los Angeles from December 10, 1888, to February 25, 1889.

Known as "Uncle John",[1] he worked as a cabinetmaker before becoming involved in the Los Angeles real estate business.

In the 1840s, he moved with his wife Emeline Sentman to Ohio and began his own carpentry business.

[2] Bryson then moved to Los Angeles, becoming involved with the real estate business.

[2] Despite being "never very active in politics", Bryson served a single term as the Mayor of Los Angeles in 1888.