[11] [12] [13][14][15][16] In 2017, Collins-Muhammad proposed a major redevelopment plan on Natural Bridge Avenue; one of the city's most derelict and less economically developed Corridors.

Natural Bridge Avenue sits in the middle of North St. Louis, and is populated by crime, a decreasing housing market, and vacant buildings.

[17] In 2018, in response to high freezing temperatures, Collins-Muhammad gained local media attention for opening up an emergency homeless shelter at St. Peter community center in his ward.

[20][21][22][23] Collins-Muhammad introduced a Board Bill creating “ban the box”, prohibiting employers in the City of St. Louis, Missouri, from basing job hiring or promotion decisions on applicants’ criminal histories.

[26] In the 2021-2022 legislative session, Collins-Muhammad served on the special COVID-19 response committee, and was successful in playing a vital role in passing legislation allocating the American Rescue Plan Act of 2021, which allocated more than $300 Million in federal funding to the City for COVID relief measures in the form of investing in housing development, grants monies for the city's Department of Health, and more than $50 Million for utility, rental, and mortgage assistance for residents.

[27] Prior to running for Alderman, Collins-Muhammad, in 2016 ran unsuccessfully for Missouri state representative of the 77th district placing second in a four-way race losing narrowly to Steve Roberts, Jr.[28] Protests erupted after a white police officer Jason Stockley was acquitted for murder in the 2011 shooting death of African-American, Anthony Lamar Smith.

Collins-Muhammad led the Board of Aldermen in unanimously approving and passing the resolution which sparked outrage from the St. Louis police officers association.

[29] Collins-Muhammad was arrested by the Florissant Police Department for failure to pay parking and traffic tickets and driving with a suspended license in Fall 2018.

Fellow Ferguson protester and Black Lives Matter surrogate Tory Russell is a known associate of Collins-Muhammad and served as his campaign manager.

[32] On May 25, 2022 Collins-Muhammad along with longtime Board of Aldermen President Lewis E. Reed and 22nd Ward Alderman Jeffrey Boyd were indicted by federal grand jury for felony corruption and bribery charges.