A National Historic Landmark, it was the home of American saxophonist and jazz pioneer John Coltrane from 1952 until 1958.

[7] In addition to its association with John Coltrane, the house has received attention due to its historic architecture.

[7] The architect is disputed; E. Allen Wilson is considered likely, due to his association with developer Clifford Pemberton,[8] but no known source specifically ties him to the Coltrane House.

"Cousin Mary," who was raised with Coltrane in High Point North Carolina, also conducted a lecture series on his life and music.

[8] Additionally, the Pennsylvania Historical & Museum Commission dedicated a marker honoring John Coltrane in front of the house on July 17, 1990.