In 2006, he was profiled in the book The Cure: How a Father Raised $100 Million – And Bucked the Medical Establishment – In a Quest to Save His Children by Geeta Anand.

degree from Notre Dame in 1992, he worked as a litigation associate in the Health Care Practice Group of the Indianapolis-based law firm of Bingham Summers Welsh & Spilman.

[8] In March 2000, Crowley left Bristol-Myers Squibb and partnered with William Canfield to start Novazyme Pharmaceuticals, a biotechnology research company located in Oklahoma City.

[2] Crowley, who became senior vice president, was in charge of Genzyme's global Pompe program, the largest R&D effort in the company's history, from September 2001 until December 2002.

In January 2003, Megan and Patrick Crowley received the enzyme replacement therapy for Pompe disease developed by Genzyme at St. Peters Hospital in New Brunswick.

[22] In the spring of 2008, Crowley was considered as a potential candidate for the Republican nomination for United States Senate in New Jersey to oppose incumbent Democrat Frank Lautenberg.

On July 22, 2008, he spoke before several hundred Congressional staffers in the Cannon House Caucus Room on the subject of biotechnology medicines and the protection of patient safety.

In July 2010, he testified before the Senate Committee on Health, Education, Labor and Pensions about the state of pediatric rare diseases research.

He is widely credited with leading the effort in 2010 to form the bi-partisan Congressional Caucus on Rare Diseases in Washington, DC.

Crowley did not run for Senate and after completing temporary active duty with the U.S. Navy Reserve, he returned to his position as CEO of Amicus in August 2011.

[24][25][26] On June 3, 2013, Senator Frank Lautenberg died, meaning that Governor Chris Christie possessed the ability to appoint a replacement.

[30] Crowley was awarded an Honorary Doctor of Science from Neumann University in Aston, Pennsylvania where he also delivered the commencement address in 2009.

In 2011, Crowley and his wife, Aileen, were given the Family Exemplar Award for their work toward finding treatments for rare diseases by the University of Notre Dame.

He received an honorary doctorate degree from the University of Notre Dame and was commencement speaker for the class of 2020 graduation, held in May 2022 as a result of the COVID-19 pandemic.

[32] Anand expanded the profile of Crowley into a book published in 2006, The Cure: How a Father Raised $100 Million – And Bucked the Medical Establishment – In a Quest to Save His Children (ISBN 978-0060734398).