John David Spence

In 2015, he received the Research Excellence Award from the Canadian Society for Atherosclerosis, Thrombosis and Vascular Biology Archived 2016-10-05 at the Wayback Machine.

In 2019, he was appointed a Member of the Order of Canada, and in 2020 he received the William Feinberg Award from the American Heart Association for excellence in clinical stroke research.

With Maria Dicicco, RVT, he pioneered the measurement of total plaque area (TPA) in a patient's carotid artery using ultrasound technology.

David Bailey and Malcolm Arnold, that grapefruit juice markedly increases blood levels of a number of drugs that have low bioavailability because of gut wall first-pass metabolism by CYP3A4 made a major contribution to the understanding of pharmacokinetics, and has opened up a new field of pharmacology.

[14] Effects of the intestinal microbiome on atherosclerosis He reported with colleagues in 2018 that patients with carotid atherosclerosis not explained by traditional risk factors had higher blood levels of toxic metabolites produced by intestinal bacteria from foods such as red meat and egg yolk.

[15] His group also found that blood levels of those toxic products are elevated with even moderate impairment of kidney function, such as seen in elderly patients.

[16] This has important implications for diet, and offers the possibility of an entirely new way of treating atherosclerosis: repopulation of the intestinal microbiome.