His father settled the manor of South Charford on his brother Herbert Doddington when he married Elizabeth Colles in 1629.
His sister Katherine Doddington married Peregrine Hoby, MP for Great Marlow, and his sister Ann Doddington married John Bulkeley, MP for Yarmouth, Newtown, Hampshire, Christchurch, Hampshire and Lymington.
[3] His paternal grandfather was William Dodington of Breamore House (who died in 1600),[4] and his maternal grandparents were Margaret (née Morgan) Herbert and Sir John Herbert of Neath Abbey who served as Secretary of State under Elizabeth I and James I.
After his brother Herbert died childless in 1633, his father held the manor of South Charford again until his death in 1638, when John inherited all his estates and Breamore House.
As all their sons died before their father, the titles passed to his younger brother, Fulke Greville, 5th Baron Brooke (1643–1710), who inherited the manor of South Charford remaining in the family until around 1748, when Francis Greville, 8th Baron Brooke sold his Hampshire estates.