[2] Ennis has played roles in Malcolm in the Middle, Tenacious D in the Pick of Destiny, and Walk Hard: The Dewey Cox Story.
In 2007, Ennis took a small part in the film Zodiac as Terry Pascoe, protégé of the handwriting expert Sherwood Morrill.
In July 2006, Ennis joined with musician and filmmaker Andrew Jon Thomson to form a cowboy harmony western comedy musical group named Saddle Pals, in the spirit of 1930s movie singing cowboy groups such as Sons of the Pioneers and contemporaries such as Riders in the Sky.
As of 2015, he stars in commercials for Smith & Forge hard cider and Pur water as well as portraying Windfall Willie for the Arizona Lottery since 2017.
In 2020, Ennis appeared as a guest on the Studio 60 on the Sunset Strip marathon fundraiser episode of The George Lucas Talk Show.