On March 24, 2007, a team of Kennedy students won the World Affairs Challenge held at San Francisco State University, sponsored by World Savvy.

[2] John F. Kennedy High School is also host to Mission Valley Regional Occupational Program, or MVROP, where students and adults attend courses in career fields including culinary arts, firefighting, automotive repair, and video production.

Kennedy High belongs to the Mission Valley Athletic League (MVAL), which comprises the high schools from Fremont, Newark Memorial of Newark, James Logan of Union City, and Moreau Catholic of Hayward.

Kennedy High School is also part of the North Coast Section (NCS).

In 2014, future major league outfielder Cal Stevenson was named the MVAL Player of the Year, playing for the Kennedy High baseball team.