He is best known for playing high school freshman Sam Weir on the NBC comedy-drama Freaks and Geeks and FBI criminal profiler Dr. Lance Sweets on the crime drama series Bones, for which he was nominated for a 2014 PRISM Award.

The duo were co-writers for Spider-Man: Homecoming (2017) with Jon Watts, Christopher Ford, Chris McKenna and Erik Sommers, and they co-directed the 2018 comedy Game Night and the 2023 fantasy Dungeons & Dragons: Honor Among Thieves.

He played Sam Weir, protagonist of the "Geeks", in the television series Freaks and Geeks, and since then he has worked continuously in television, including series such as The Geena Davis Show, Boston Public, Regular Joe, Kitchen Confidential, Judging Amy, and Spin City.

[citation needed] Sweets was ultimately killed in the season 10 premiere; Bones executive producer Stephen Nathan said Sweets was killed because Daley wanted time off to direct a movie, and he was concerned that Daley's absence would be too long, especially if the directing job led to other jobs.

[13] Daley and Goldstein wrote the screenplay for the 2017 film Spider-Man: Homecoming with four other screenwriters,[14] and were both considered to direct[15] before Jon Watts was hired.

The film, starring Jason Bateman and Rachel McAdams, "earned a raft of glowing reviews for its whip-smart script, energetic performances, and deliberate avoidance of modern comedy's ubiquitous tropes," and grossed $117 million at the worldwide box office, versus a $37 million budget.

[19][20] In July 2019, it was announced that Goldstein and Daley were entering early negotiations to direct the reboot of Dungeons & Dragons: Honor Among Thieves (2023).