USS Sheehan (DE-541) was a United States Navy John C. Butler-class destroyer escort launched during World War II but never completed.

Sheehan was killed on the night of 5 September 1942, when Gregory was sunk by gunfire from an Imperial Japanese Navy cruiser and three destroyers during the Naval Battle of Guadalcanal.

Desperately overmatched by the four Japanese ships and, despite a gallant effort by its crew, Gregory dead in the water within three minutes.

After Gregory's crew had abandoned ship, the Japanese began shelling the helpless survivors in the water, killing 11, including Sheehan.

On 7 January 1946, the contract for her construction was cancelled, and the incomplete ship was sold on 2 July 1946 to the John J. Duane Company of Quincy, Massachusetts, for scrapping.