[1] Fru Ndi attended school in Cameroon at the Baforchu Basel Mission and the Santa Native Authority before going to Nigeria to study (at Lagos City College) and work in 1957.

[7] Amidst the outbreak of violence in the North-West Province that followed the election, Fru Ndi was placed under house arrest[7][8] in late October 1992.

[7] On 20 January 1993, Fru Ndi, along with his wife Rose, attended the inauguration of United States President Bill Clinton.

[10] Fru Ndi was re-elected as SDF Chairman at the party's fifth congress in April 1999, receiving 1,561 votes from delegates against 40 for his challenger, Chretien Tabetsing.

Fru Ndi indicated that he believed the 2008 changes to the Constitution were intended to enable President Biya to be lifelong dictator of Cameroon and that the changes would institutionalize corruption, immunity, and inertia.

[18] In the April 2013 Senate election, Fru Ndi stood as a candidate in the Northwest Province, his primary support base.

[19] Fru Ndi took a critical stance against the Cameroonian government's handling of the Anglophone Crisis, a war that affected him personally.

[21] Eight days later he was kidnapped himself, while visiting Kumbo, Northwest Region to attend the funeral of Joseph Banadzem, the Parliamentary group leader of the SDF.

[24] Fru Ndi made a point of always travelling without a security escort whenever he visited the Anglophone regions, stating that he was not afraid of his own people – including separatists.

Despite his efforts to promote peace, Fru Ndi faced criticism from some anglophone activists, who accused him of not doing enough to challenge the government's actions.