John Guier Scott (December 26, 1819 – May 16, 1892) was a U.S. Representative from Missouri.

Born in Philadelphia, Pennsylvania, Scott completed preparatory studies.

He was an unsuccessful Democratic candidate for election in 1862 to the Thirty-eighth Congress.

Scott was subsequently elected as a Democrat to the Thirty-eighth Congress to fill the vacancy caused by the death of John W. Noell and served from December 7, 1863, to March 3, 1865.

He died at Oliver Springs, Tennessee, on May 16, 1892, and was interred at Bellefontaine Cemetery in St. Louis, Missouri.