Prior to the independence itself, Guise was a vocal advocate for a peaceful secession from Australia.

He was born in Gedulalara village, near Dogura, and was educated there at the mission school of a church in Milne Bay District.

His grandfather was Reginald Guise, an English adventurer who reached Papua in the 1880s, settled as a trader and married locally.

[2] He served in the Department of Native Affairs during the 1950s, and became the president of the Port Moresby Mixed Race Association in 1958.

[4] He remained politically active and considered as a potential leader during the civil unrest after his term in office.