John Vogel Guttag (born March 6, 1949) is an American computer scientist, professor, and former head of the department of electrical engineering and computer science at MIT.

He conducts research on computer networks and medical applications of AI as co-lead of the MIT Computer Science and Artificial Intelligence Laboratory's Networks and Mobile Systems Group.

EECS, with approximately 2000 students and 125 faculty members, is the largest department at MIT.

He helped student Vanu Bose start a company with software-defined radio technology developed at MIT.

He is one of the founders of Health[at]Scale Technologies, a machine learning and artificial intelligence company.