John Holmes Overton Sr. (September 17, 1875 – May 14, 1948), was an attorney and Democratic US Representative and US Senator from Louisiana.

Another distant relative was Thomas Overton Moore, the governor of Louisiana during the American Civil War.

In 1932, Overton unseated the two-term US Senator Edwin S. Broussard, of New Iberia, for the Democratic nomination, then equivalent to election in Louisiana.

A Senate investigating committee held months of hearings beginning in February 1933, but Overton was nevertheless seated without opposition on March 4, the first day of the congressional session.

As a senator, Overton generally voted with the Conservative Coalition of Midwestern Republicans and Southern Democrats, much like Broussard.

Overton's last term was cut short by his death at National Naval Medical Center in Bethesda, Maryland.

[citation needed] His remains were buried at Mount Olivet Cemetery in Pineville in Rapides Parish.

[citation needed] In 1998, Overton was posthumously inducted into the Louisiana Political Museum and Hall of Fame in Winnfield.