John Hamilton House, also known as the Hamilton House, is a historic home located at Shelbyville, Shelby County, Indiana.

It was built in 1853, and is a 2+1⁄2-story, rectangular, Italianate style brick dwelling.

It has a slate roof and sits on a limestone block foundation.

The front facade features segmental arched windows, and two two-story projecting polygonal bays flanking a semi-circular one-story porch supported by Doric order columns added about 1910.

This article about a property in Shelby County, Indiana on the National Register of Historic Places is a stub.