[3] He was the older brother of former Cebu governor Emilio Mario "Lito" Osmeña Jr. and Annabelle "Annie" Osmeña-Aboitiz, a real estate developer.

[3] Running for the Senate in 1971, Osmeña was at the August 21, 1971 miting de avance of the Liberal Party in Plaza Miranda, Quiapo, Manila where two grenades exploded killing 11 and leaving several people wounded.

[6] When President Ferdinand Marcos declared martial law on September 23, 1972, Osmeña went on exile in the United States.

[3] After the assassination of former Senator Benigno “Ninoy” Aquino on August 21, 1983, he was among the first political exiles to return to the country to help in the fight against the Marcos dictatorship.

[3] In 1992, he ran for vice president under the Nationalist People's Coalition with businessman Eduardo Cojuangco Jr. as his running mate.

They only had one son, John Gregory "John-John" Osmeña, a former Cebu vice governor and provincial board member.

Osmeña died on February 2, 2021, sixteen days after his 86th birthday, at his unit at Maryville Condominiums in Cebu City from post-COVID-19 complications.

[12] His remains were cremated and later inurned on the next day at Skyline Garden Columbary in Cebu City after his funeral that lasted less than an hour.