Sir John Houblon (13 March 1632 – 10 January 1712) was an English merchant and banker who served as the first governor of the Bank of England from 1694 to 1697.

The Houblon family were Huguenots from Lille and he later became an elder in the French Protestant Church of London in Threadneedle Street.

His older brother, James, an influential merchant and Member of Parliament for the City of London, was also a director of the Bank of England.

The design includes an image of Houblon's house in Threadneedle Street, the site of the present Bank of England building.

[6] A new £50 note was brought into circulation in 2011, featuring James Watt and Matthew Boulton in place of Sir John Houblon.