John Houghton, OCart (c. 1486 – 4 May 1535) was a Catholic priest of the Carthusian order and the first martyr to die as a result of the Act of Supremacy by King Henry VIII of England.

"[2] He asked that he and his community be exempted from the oath required under the new Act of Succession, which resulted in both him and his procurator, Humphrey Middlemore, being arrested and taken to the Tower of London.

However, by the end of May, they had been persuaded that the oath was consistent with their Catholicism, with the clause "as far as the law of Christ allows" and they returned to the Charterhouse, where (in the presence of a large armed force) the whole community made the required professions.

[2] However, in 1535, the community was called upon to make the new oath as prescribed by the 1534 Act of Supremacy, which recognised Henry as the Supreme Head of the Church of England.

From his prison cell in the Tower, Thomas More saw the three Carthusian priors being dragged to Tyburn on hurdles and exclaimed to his daughter: "Look, Meg!

There is a mosaic of Houghton in the Holy Name of Jesus Roman Catholic Church, Oxford Road, Chorlton-on-Medlock, Manchester.