John Joseph Kain (May 31, 1841 – October 13, 1903) was an American Catholic prelate who served as Bishop of Wheeling from 1875 to 1893 and as the first American-born Archbishop of Saint Louis from 1896 to 1903.

[citation needed] Kain was ordained to the priesthood by Archbishop Martin John Spalding on July 7, 1866, for the Diocese of Wheeling.

[6] Pope Pius IX appointed Kain as bishop of the Diocese of Wheeling on February 12, 1875.

He was consecrated at the Cathedral of Saint Joseph in Wheeling by Archbishop James Bayley on May 23, 1875.

[2] John Kain died on October 13, 1903, in St. Agnes' Sanitarium in Baltimore after a long illness.