Kerr became the White Sox starting second baseman in 1929, replacing Bill Hunnefield, who would be traded to the Toledo Mud Hens in midseason.

Kerr missed parts of the 1930 season with various injuries, winding up as the backup middle infielder behind Bill Cissell and Greg Mulleavy.

After the season, he was traded to the Senators with outfielder Carl Reynolds in exchange for pitchers Bump Hadley and Sad Sam Jones, as well as infielder Jackie Hayes, who would replace him as the starting second baseman.

Kerr spent the next three seasons on the Senators' bench behind second baseman Buddy Myer and future Hall of Fame shortstop Joe Cronin.

Kerr's sole appearance came in the finale (Game 5) when he pinch ran for centerfielder Fred Schulte with 2 out in the bottom of the 10th inning.