[6] From the mid-1960s until 1986 Large was an academic in Brunel University's School of Engineering, becoming a lecturer in 1971, where he undertook research for the United Kingdom Atomic Energy Authority, particularly on the Advanced Gas-cooled Reactor design.
[2][3] The International Atomic Energy Agency (IAEA) invited Large to visit China, Korea and Iran to give advice on their nuclear programmes.
He visited Japan on behalf of Greenpeace following the Fukushima Daiichi nuclear disaster, and his first technical assessment confirmed a triple reactor meltdown well before it was officially acknowledged.
[6][22][23] In 1985 Large was invited by House of Commons Environment Committee to submit evidence on environmental issues associated with radioactive waste at the UK's irradiated fuel reprocessing works at Sellafield.
He provided the Committee with a technical note on the breakaway corrosion of Magnox nuclear fuel, demonstrating the then hitherto undisclosed highly unstable pyrophoric reaction.
[2][6] Large and his partner lived in a converted neoclassical gatehouse of the Royal Artillery Barracks in Woolwich, London,[6][28] which they had renovated from a damaged and neglected condition.