John MacDonald (c. 1727 – 9 May 1779) was a Roman Catholic bishop who served as the Vicar Apostolic of the Highland District of Scotland.
Born in Ardnamurchan, Argyllshire in about 1727, he was ordained a priest on 1 April 1752.
He was appointed the Coadjutor Vicar Apostolic of the Highland District and Titular Bishop of Tiberiopolis by the Holy See on 25 February 1761.
He was consecrated to the Episcopate at Preshome on 27 September 1761.
On the death of Bishop MacDonald on 12 March 1773, he automatically succeeded as the Vicar Apostolic of the Highland District.