John Francis Maisto (born August 28, 1938, Braddock, Pennsylvania) is a retired U.S. career diplomat, who rose from Foreign Service Officer to eventually serve as a U.S.

Early postings included working with the State Department's Information Agency in Argentina and Bolivia.

In 1993, Maisto was nominated by President Bill Clinton to be the United States Ambassador to Nicaragua, serving in that position until November 1996.

In January 2001, with the inauguration of President George W. Bush, Maisto was brought in as a Special Assistant to the President and Senior Director for Western Hemisphere Affairs to National Secretary Advisor Condoleezza Rice.

In 2003, President Bush nominated Maisto to be the Ambassador to the Organization of American States, serving until March 2007.