He was the eldest son and heir of Sir George Manners (1569–1623) of Haddon Hall in Derbyshire, the eldest son and heir of Sir John Manners (bef.1535–1611), the second son of Thomas Manners, 1st Earl of Rutland of Belvoir Castle.

He was admitted at Queens' College, Cambridge, in spring 1619 and was awarded MA in 1621.

[4] After the Restoration of the Monarchy he was appointed By King Charles II as Lord Lieutenant of Leicestershire on 14 February 1667 and held the post until 7 July 1677.

[4] In 1628, he married Frances Montagu, a daughter of Edward Montagu, 1st Baron Montagu of Boughton, by whom he had one son and six daughters as follows: In 1677, a legal case before the House of Lords ruled on a legal dispute between Manners and Scrope Howe over the financial settlement made for Lady Anne and her heirs.

[7] He died aged 75 and was buried in St Mary the Virgin's Church, Bottesford, Leicestershire,[4] where survives his monument.