John Battista Mastrangelo (March 10, 1926 – October 2, 1987) was an American professional football player in the National Football League (NFL).

He made his NFL debut in 1947 with the Pittsburgh Steelers.

Prior to joining the NFL, Mastrangelo played college football for the Notre Dame Fighting Irish, twice receiving first-team All-American honors.

"An All-American on Notre Dame's great 1946 eleven... A big, fast fellow who runs like a halfback Wears contact lenses... President of his class at Notre Dame.. Smart and aggressive... Will develop into one of the best linemen in the league."

This biographical article relating to an American football offensive lineman born in the 1920s is a stub.