He was defeated by Democrat Stephanie Murphy in the November 8, 2016, general election while serving his 12th term in office.

Mica won the Republican primary with 53% of the vote, defeating State Representative Richard Graham (34%) and Vaughn Forrest (13%).

[6] For his first 10 terms, Mica represented a district that stretched from the Orlando suburbs through Daytona Beach all the way to St. Augustine.

However, most of the Orange County portion, including Mica's home in Winter Park, was drawn into the new 7th District.

The new map cut out the district's share of Volusia County, while pushing it farther into Orlando.

[11] In November 1997, Mica was one of eighteen Republicans in the House to co-sponsor a resolution by Bob Barr that sought to launch an impeachment inquiry against President Bill Clinton.

[23] In 2009, he earmarked $13 million for the Central Florida Commuter Rail, which was supported by a client of Mica's daughter.

[24] Mica has been opposed to the federal government contributing any additional funds towards repairing the Washington DC Metrorail system.

[25] As chairman of the House Oversight Committee's subcommittee on government operations, Mica convened a hearing on marijuana legalization in 1999.

[27][28] Another such hearing was held by Mica in 2014 on the same subject, with multiple drug experts providing input.