The John Monash Science School is a government-funded co-educational academically selective and specialist secondary day school, located on the Clayton campus of Monash University, in Melbourne, Victoria, Australia.

[1] A joint venture between the Government of Victoria and Monash University, the school opened in 2009 with one Year 10 class;[2] and as of 2010 it was running at its full capacity of approximately 660 students.

Entry into John Monash Science School is highly selective, with students first being required to sit an entrance exam (administered by EduTest), testing scientific and mathematical amplitude.

Additionally, the school frequently ranks within the top 10 for VCE Chemistry, Algorithmics(HESS) and Biology in the state.

[8] Utilizing the Australian government's National Broadband Network's (NBN) educational facilities, lessons are taught by JMSS staff and Monash University scientists via internet to schools all around Australia.