Originally from Mechelen in what is now Belgium, he moved to England in the second half of the 17th century, gaining employment with the sculptor Arnold Quellin as a foreman.
After Quellin's death in 1686, Nost married his widow, and established his own sculptural works business in the Haymarket district of London.
Van Nost died at his home at Hyde Park in London on 26 April 1729.
Van Nost was heavily involved with other well-known sculptors of the day.
[citation needed] Several well-known sculptors had their premises near Nost at the Haymarket and it is known that he collaborated with many of them.