John Paul II Catholic High School (JPII), located in Greenville, North Carolina is a four-year private coeducational college-preparatory Catholic high school.

In 2010, Pope John Paul II High School in Greenville, North Carolina, became the second diocesan high school in the Diocese of Raleigh.

It added grades 10–12 as students advanced through the 2013–2014 school year.

[2] The high school expansion mirrors growth in other areas of the diocese.

Diocese of Raleigh Bishop Luis Rafael Zarama and Superintendent of Catholic Schools Lytia Reese previously announced the transition on January 22, 2021.