[1] Middleton's production company, The Affleck/Middleton Project, produced the film Manchester by the Sea (2016), which was nominated for six Oscars, including Best Picture.

[3] He also served as an executive producer on The Disaster Artist (2017), which was chosen by the National Board of Review as one of the top ten films of 2017.

[12] John Powers Middleton began his career as an intern, assistant, and script supervisor for a number of companies and productions before partnering with Roy Lee under his Vertigo Entertainment banner in the fall of 2010.

[13] In February 2013, Middleton and Lee entered a joint venture with Joe Drake and Nathan Kahane to launch Good Universe, an independent full-service film financing, production, and global sales company.

[1][16] Through these partnerships Middleton produced: The Lego Movie (2014), the A&E show Bates Motel, a reboot of the classic horror film Poltergeist, the Liam Neeson/Ed Harris thriller Run All Night, and Spike Lee's Oldboy, among others.

[23] Middleton was an executive producer on The Disaster Artist (2017),[24] which was nominated for two Golden Globe Awards, including the Best Musical or Comedy Motion Picture.

[28] Middleton is active in Republican fundraising, political strategy, the youth movement, and media, with his first effort in creating and producing The Alfonso Aguilar Show.